Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
Abstract Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD…
Molecular biology
Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-88917-1. Article type: Research Article Keywords: Ovarian cancer, Lipid…
Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Abstract The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological…
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Abstract Background: The link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use.…
Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment…
Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use
Abstract Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve…
PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice
Abstract Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that regulate gene expression. Δ9-tetrahydrocannabinol (Δ9-THC) is a PPARγ…
Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows
Abstract Metabolic disorders are often linked to alterations in insulin signaling. Omega-3 (n-3) fatty acids modulate immunometabolic responses; thus, we…
Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice
Abstract Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine…
Cannabidiol affects breast meat volatile compounds in chickens subjected to different infection models
Abstract No study has demonstrated the use of dietary Cannabis-derived cannabidiol (CBD) to alter the stress response in chickens or…