Molecular Docking of Natural Compounds as DPP-4 Inhibitors in Type 2 Diabetes: A Comprehensive Review
Abstract Dipeptidyl peptidase-4 (DPP-4) is an established therapeutic target in the treatment of type 2 diabetes mellitus (T2DM), primarily due…
Drug discovery
Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders
Abstract Endocannabinoids (eCBs) are lipid-derived neuromodulators that regulate numerous neurophysiological processes by modulating synaptic transmission. Synthesised on demand in response…
Effect of cannabidiol, cannabinol and tetrahydrocannabivarin in managing inflammatory pain
Abstract Current medications used to treat the inflammatory pain either have limited effectiveness or may be associated with serious side…
In vivo evaluation of synthetic cannabinoid JWH-018 derivatives as potential new psychoactive substances
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-51639-z. Article type: Research Article Keywords: Drug discovery, Medical…
Cannabidiol at the crossroads: panacea, placebo, or problem?
Abstract Cannabidiol (CBD) is widely perceived as a safe and effective treatment for a growing list of health indications and…
Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-43045-2. Article type: Research Article Keywords: Cannabis, THC, Simulated…
Cannabidiolic acid as a modulator of lipid metabolism in the liver of rats with metabolic-associated steatotic liver disease
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-41130-0. Article type: Research Article Keywords: Cannabidiolic acid (CBDA),…
Exploring the chemical space around Cannabis sativa L. leaves as a source of bioactive compounds of pharmaceutical interest
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-39088-0. Article type: Research Article Keywords: Leaves, Polyphenols, Cannabinoids,…
Hemp seed extract exerts cytostatic effects through metabolic stress and autophagy modulation in malignant cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-37119-4. Article type: Research Article Keywords: Biochemistry, Cancer, Cell…
Cannabidiol mitigates high-fat-diet-induced early-stage inflammation in two adipose tissue fat depots of Wistar rats
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-36666-0. Article type: Research Article Keywords: Adipose tissue, Cannabidiol,…