Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis
Abstract PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and acts as a transcriptional cofactor of HOX…
DNA methylation
Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner
Abstract Cannabis is increasingly consumed by women of childbearing age, and the reproductive and epigenetic effects are unknown. The purpose…
Pan-Cancer Methylated Dysregulation of Long Non-coding RNAs Reveals Epigenetic Biomarkers
Abstract Different cancer types not only have common characteristics but also have their own characteristics respectively. The mechanism of these…
Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
Abstract Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection…
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Abstract Background: Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain…
Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
Abstract Simple Summary: Promoter mutations of the telomerase reverse transcriptase (TERT) gene have been suggested as an oncogenic event in…
Pan-Cancer Transcriptome and Immune Infiltration Analyses Reveal the Oncogenic Role of Far Upstream Element-Binding Protein 1 (FUBP1)
Abstract Despite increasing evidence to support the relationship between FUBP1 and tumorigenesis in some types of cancers, there have been…
Deciphering the etiology and role in oncogenic transformation of the CpG island methylator phenotype: a pan-cancer analysis
Abstract Numerous cancer types have shown to present hypermethylation of CpG islands, also known as a CpG island methylator phenotype…
Alternative Splicing, Epigenetic Modifications and Cancer: A Dangerous Triangle, or a Hopeful One?
Abstract Simple Summary: Epigenetics studies the alteration of gene expression without changing DNA sequence and very often, epigenetic dysregulation causes…
Pan-Cancer DNA Methylation Analysis and Tumor Origin Identification of Carcinoma of Unknown Primary Site Based on Multi-Omics
Abstract The metastatic cancer of unknown primary (CUP) sites remains a leading cause of cancer death with few therapeutic options.…