Charting differentially methylated regions in cancer with Rocker-meth
Abstract Differentially DNA methylated regions (DMRs) inform on the role of epigenetic changes in cancer. We present Rocker-meth, a new…
DNA methylation
Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis
Abstract Background: Detecting prostate cancer at a non-aggressive stage is the main goal of prostate cancer screening. DNA methylation has…
Refraining from use diminishes cannabis-associated epigenetic changes in human sperm
Abstract Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis…
A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors
Abstract Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions and is pursued as an…
An Examination of Risk Factors for Tobacco and Cannabis Smoke Exposure in Adolescents Using an Epigenetic Biomarker
Abstract Objective: Evolving patterns of nicotine and cannabis use by adolescents require new tools to understand the changing epidemiology of…
Aggresome–Autophagy Associated Gene HDAC6 Is a Potential Biomarker in Pan-Cancer, Especially in Colon Adenocarcinoma
Abstract Background: Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through the deacetylation of various cytoplasmic substrates. Recent studies have…
Machine Learning Approaches to Classify Primary and Metastatic Cancers Using Tissue of Origin-Based DNA Methylation Profiles
Abstract Simple Summary: Cancer metastasis is considered to be one of the most significant causes of cancer morbidity, accounting for…
Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology
Abstract Background: The vault RNAs (vtRNAs) are a class of 84-141-nt eukaryotic non-coding RNAs transcribed by RNA polymerase III, associated…
Analysis of the Prognostic Value and Potential Molecular Mechanisms of TREM-1 Overexpression in Papillary Thyroid Cancer via Bioinformatics Methods
Abstract Background: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been reported as a biomarker in many cancers. However, the…
Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation
Abstract Background: Disruption of DNA methylation (DNAm) is one of the key signatures of cancer, however, detailed mechanisms that alter…