Dynamic changes of synergy relationship between lncRNA and immune checkpoint in cancer progression
Abstract In the battle between tumors and the immune system, immune evasion based on immune checkpoints (ICPs) is a critical…
adoptive cellular immunotherapy
Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma
Abstract Background: Cancer immunotherapy has revolutionized treatment, yet predicting patient responses remains challenging. The potential of nuclear receptor coactivator 4…
RNF213 governs divergent tumor-immune dynamics across human cancers: a prognostic biomarker for immunotherapy stratification
Abstract Purpose: RNF213 encodes one of the largest E3 ubiquitin ligases in the human proteome, playing essential roles in ubiquitination,…
Interplay of disulfidptosis and the tumor microenvironment across cancers: implications for prognosis and therapeutic responses
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-025-14246-1. Article type: Research Article Keywords: Pan-cancer, Disulfidptosis, Prognosis,…
Pan-cancer analysis of polycomb repressive complex 1 (PRC1) in relation to prognosis and immunotherapy response
Abstract Introduction: Polycomb repressive complex 1 (PRC1) is a crucial epigenetic modification complex that plays significant roles in embryonic development,…
A Pan‐Cancer Study of Tumour‐Associated Efferocytosis Core Genes and Preliminary Exploration of TIMD4 in Renal Cell Carcinoma
Abstract Efferocytosis plays a crucial role in maintaining the stability of the immune microenvironment. Increasing research indicates that efferocytosis core…
Prognostic and immunological landscape of DDX17 in pan-cancer analysis: a comprehensive study
Abstract Objective: DDX17, an ATP-dependent RNA/DNA helicase, is implicated in the regulation of RNA metabolism and has been linked to…
Multi-omics analysis of tumor necrosis factor superfamily 4 reveals its prognostic value with T cell exhaustion feature in cancer
Abstract Background: As a member of the tumor necrosis factor (TNF) family, TNF superfamily 4 (TNFSF4) plays a crucial role…
Beyond Transposons: TIGD1 as a Pan-Cancer Biomarker and Immune Modulator
Abstract Background/Objectives: TIGD1 (Trigger Transposable Element Derived 1) is a recently identified oncogene with largely unexplored biological functions. Emerging evidence…
Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy
Abstract Background: Transmembrane emp24 domain-containing protein 2 (TMED2) is involved in the sorting and transport of proteins between the Golgi…