Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-022-01436-2. Article type: Research Article Keywords: Down syndrome, Tau,…
Abstract Hemp (Cannabis sativa L., 2n = 20) is a valuable crop that is successfully used as a food, technical…
Abstract Molecular chaperones safeguard cellular protein homeostasis and obviate proteotoxicity. In the process of aging, as chaperone networks decline, aberrant…
Abstract Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed…
Abstract Genome‐wide association studies have described several genes as genetic susceptibility loci for Alzheimer’s disease (AD). Among them, CD2AP encodes…
Abstract The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as Alzheimer’s disease.…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-021-01196-5. Article type: Research Article Keywords: TAU, Cannabinoid receptor,…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-021-02318-y. Article type: Research Article Keywords: Tau, Immunotherapy, Gosuranemab,…
Abstract Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in…
Abstract Background: Alzheimer’s disease (AD) is characterized by structural damage, death, and functional disruption of cholinergic neurons (ChNs) as a…