Prenatal fentanyl and Δ9-tetrahydrocannabinol exposure disrupt placental function and fetal growth in a mouse model of multidrug use

Yusmaris Cariaco, Nikita Larionov, Abolfazl Nik-Akhtar, Jessica Pudwell, Kira King, Laura Gaudet +1 more

Opioid and cannabis co-use during pregnancy is increasingly common, yet the placental mechanisms linking combined exposure to adverse fetal outcomes remain poorly defined. Using a controlled mouse model of gestational drug exposure, we tested how fentanyl, {Delta}9-tetrahydrocannabinol (THC), or their combination altered placental structure, immune signaling, and gene expression and how these changes related to fe…