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Research Article 2022CC BYFree full text

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.

Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li, Peizhao Liu +7 more

The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding of immunopathy. While the detrimental effects of STING during sepsis had been well documented, the exact mechanism by which STING causes lethal sepsis remains obscure. Through single-cell RNA sequence, genetic approaches, and mass spectrometry, we demonstrate that STING promotes sepsis-induced multiple organ injur…

Cell Death & Disease Europe PMC

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Research Article 2018-12-27CC BYFree full text

Causes of death among hospitalized adults with dengue fever in Tainan, 2015: emphasis on cardiac events and bacterial infections

Jen-Chieh Lee, Cong-Tat Cia, Nan-Yao Lee, Nai-Ying Ko, Po-Lin Chen, Wen-Chien Ko

IntroductionThe 2015 dengue outbreak in southern Taiwan caused substantial mortality rates in the elderly. We analyzed here the causes of death among adults with dengue.\n\nMethodsThe retrospective study was conducted at a medical center in Tainan from the 1st of August to 31th of December in the year 2015. The detection of the dengue NS1 antigen IgM or viral RNA in patients blood were used to diagnose dengue. Cli…

bioRxiv bioRxiv

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