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Research Article 2025CC BYFree full text

Association between non-adherence to fish oil or placebo as a risk factor of transition to psychosis in ultra-high-risk individuals in the NEURAPRO study.

Monika Schlögelhofer, Ashleigh Lin, Connie Markulev, Miriam R Schäfer, Patrick D McGorry, Barnaby Nelson +14 more

Objective Non-adherence is an important factor in clinical trials, which has not been investigated in people at ultra-high risk (UHR) of developing a first episode of psychosis. Methods Exploratory analysis of data from NEURAPRO, a multicenter, placebo-controlled trial of long-chain omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in 304 individuals at UHR. We examined correlates of non-adherence with study med…

The Australian and New Zealand Journal of Psychiatry Europe PMC

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Research Article 2020CC BYFree full text

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis.

E. Appiah-Kusi, N. Petros, R. Wilson, M. Colizzi, M. G. Bossong, L. Valmaggia +3 more

Rationale Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic and anxiolytic effects. Objectives We investigated whether CBD would normalise the neuroendocrine and anxiety responses to stress in clinical high risk for psychosis (CHR) patients. Methods Thirty-two CHR patients and 26 healthy controls (HC) took part in the Trier Socia…

Psychopharmacology Europe PMC