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Research Article 2025CC BY-NCFree full text · non-commercial reuse

Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology.

Zhuo-Cong Bao, Ye Zhang, Zhao-Dong Liu, Hui-Jun Dai, Fu Ren, Ning Li +2 more

Background Hepatocellular carcinoma (HCC) is a malignant disease with high incidence and mortality worldwide. This study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin (THC) on HCC and its mechanism of action. The research hypothesis is that THC can inhibit the proliferation, migration, and invasion of HCC cells, and promote their apoptosis by regulating th…

World Journal of Gastrointestinal Oncology Europe PMC

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Research Article 2021CC BYFree full text

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors.

Aleksandra Ellert-Miklaszewska, Iwona Anna Ciechomska, Bozena Kaminska, Marco Falasca, Mauro Maccarrone

Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic alterations in TP53 and PTEN tumor suppressor genes rendering resistance to standard chemotherapeutics. Cannabinoid type 1 and 2 (CB1/CB2) receptor expression in GBMs and antitumor activity of cannabinoids in glioma cells and animal models, raised promises for a targeted treatment of these tumors. The susceptibility of human glioma cells to CB2…

Cancers Europe PMC

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