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Author: Bozena Kaminska

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Research Article 2021CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors.

Aleksandra Ellert-Miklaszewska, Iwona Anna Ciechomska, Bozena Kaminska, Marco Falasca, Mauro Maccarrone

Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic alterations in TP53 and PTEN tumor suppressor genes rendering resistance to standard chemotherapeutics. Cannabinoid type 1 and 2 (CB1/CB2) receptor expression in GBMs and antitumor activity of cannabinoids in glioma cells and animal models, raised promises for a targeted treatment of these tumors. The susceptibility of human glioma cells to CB2…

Cancers Europe PMC↗

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Research Article 2015CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text