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Research Article 2020CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Long-Term Low-Dose Delta-9-Tetrahydrocannbinol (THC) Administration to Simian Immunodeficiency Virus (SIV) Infected Rhesus Macaques Stimulates the Release of Bioactive Blood Extracellular Vesicles (EVs) that Induce Divergent Structural Adaptations and Signaling Cues.

Yuan Lyu, Steven Kopcho, Mahesh Mohan, Chioma M. Okeoma

Blood extracellular vesicles (BEVs) carry bioactive cargo (proteins, genetic materials, lipids, licit, and illicit drugs) that regulate diverse functions in target cells. The cannabinoid drug delta-9-tetrahydrocannabinol (THC) is FDA approved for the treatment of anorexia and weight loss in people living with HIV. However, the effect of THC on BEV characteristics in the setting of HIV/SIV infection needs to be det…

Extracellular Vesicles (Evs)Siv/hiv Delta-9-tetrahydrocannbinol (Thc)Animals Macaca mulatta Simian Acquired Immunodeficiency Syndrome Male

Cells Europe PMC↗

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