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Research Article 2026CC BYFree full text

Cannabidiol-rich extract suppresses the activation of proinflammatory genes IL-1β and IL-6 in equine mesenchymal stem cells stimulated with lipopolysaccharide.

Beatriz da Costa Kamura, Lucas Vinícius de Oliveira Ferreira, Natielly Dias Chimenes, João Pedro Marmol de Oliveira, Diego Noe Rodriguez-Sanchez, Márcio de Carvalho +1 more

Peripheral nerve injuries (PNI) often lead to long-term functional impairment. Mesenchymal stem cells (MSCs) and cannabidiol (CBD) have shown anti-inflammatory and neuroprotective effects in vitro, which may be relevant for PNI research. The aim of this study was to evaluate CBD-rich cannabis extract’s potential to induce anti-inflammatory and neurotrophic gene expression in equine adipose tissue-derived MSCs (EqA…

Veterinary Research Communications Europe PMC

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Research Article 2022CC BYFree full text

Influence of N-Arachidonoyl Dopamine and N-Docosahexaenoyl Dopamine on the Expression of Neurotrophic Factors in Neuronal Differentiated Cultures of Human Induced Pluripotent Stem Cells under Conditions of Oxidative Stress.

Ekaterina Novosadova, Oleg Dolotov, Ludmila Inozemtseva, Ludmila Novosadova, Stanislav Antonov, Darya Shimchenko +6 more

Oxidative stress (OS) is implicated in the pathogenesis of several neurodegenerative diseases. We have previously shown that N-acyl dopamines (N-ADA and N-DDA) protect the neural cells of healthy donors and patients with Parkinson's disease from OS. In this study, we assessed the effects of N-acyl dopamines on the expression of neurotrophic factors in human-induced pluripotent stem cell-derived neuronal cultures e…