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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
6 articles
Newest firstMarijuana use in the United States (U.S.) has diversified alongside expanding legalization, yet little is known about the psychosocial factors that distinguish medical from recreational use. This study examined whether psychological distress mediates the association between perceived social isolation (i.e., loneliness) and marijuana use type among U.S. adults. We analyzed cross-sectional, nationally representative…
Open article record in new tab ↗Background Adolescent substance use initiation is shaped by multiple genetic and neurobiological factors. Externalizing liability, a transdiagnostic genetic dimension capturing shared predisposition to impulsivity, disinhibition, and related traits, is among the strongest polygenic predictors of early substance initiation. Yet how this genetic risk relates to brain structure and function, and whether baseline brai…
Open article record in new tab ↗BackgroundEmpirical evidence suggests that people use cannabis to ameliorate anxiety and depressive symptoms, yet cannabis also acutely worsens psychosis and affective symptoms. However, the temporal relationship between cannabis use, anxiety and depressive symptoms and psychotic experiences (PE) in longitudinal studies is unclear. This may be informed by examination of mutually mediating roles of cannabis, anxiet…
Highlights•People living with HIV (PWH) with substance use or alcohol use often have detectable plasma HIV viral loads that are predictive of negative clinical outcomes.•Among PWH with substance or alcohol use, it is not known what proportion of the observed detectable HIV viremia is mediated through medication nonadherence.•Use of amphetamines, opioids, and multiple substances but not alcohol predicted having a d…
Open article record in new tab ↗Drugs of abuse are widely known to worsen mental health problems, but this relationship may not be a simple causational one. Whether or not a person is susceptible to the negative effects of drugs of abuse may not only be determined by their addictive properties, but also the users' chronotype, which determines their daily activity patterns. The present study investigates the relationship between chronotype, drug…
Open article record in new tab ↗OBJECTIVE: To investigate whether cannabis use is associated with increased risk of relapse, as indexed by number of hospital admissions, and whether antipsychotic treatment failure, as indexed by number of unique antipsychotics prescribed, may mediate this effect in a large data set of patients with first episode psychosis (FEP). DESIGN: Observational study with exploratory mediation analysis. SETTING: Anonymised…
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