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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstSimple SummaryThis article reviews the roles of lipid mediators as potential therapeutic targets in prostate cancer. Lipid mediators are derived from more complex cellular phospholipids and some come from the diet. The major mediators discussed are sphingosine 1-phosphate, lysophosphatidic acid, prostaglandin E2, thromboxane A2, lipoxin A4, endocannabinoids, and omega-3 fatty acids. All activate distinct druggable…
Open article record in new tab ↗We have recently reported sex differences in the plasma concentrations of lysophosphatidic acid (LPA) and alterations in LPA species in patients with alcohol and cocaine use disorders. Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in anxiogenic responses and drug addiction. To further explore the potential role of the LPA signaling system in sex differences and psychiatric como…
Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lysophosphatidic acid (LPA) are examples of this type of molecule and are involved in neuroprotection…
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