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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstBackground Substance misuse presents significant global public health challenges. Understanding transitions between substance types and the timing of shifts to polysubstance use is vital to developing effective prevention and recovery strategies. The gateway hypothesis suggests that high-risk substance use is preceded by lower-risk substance use. However, the source of this correlation is hotly contested. While so…
Open article record in new tab ↗Background and aims Initial use of drugs such as tobacco and alcohol may lead to subsequent more problematic drug use-the 'gateway' hypothesis. However, observed associations may be due to a shared underlying risk factor, such as trait impulsivity. We used bidirectional Mendelian randomization (MR) to test the gateway hypothesis. Design Our main method was inverse-variance weighted (IVW) MR, with other methods inc…
Open article record in new tab ↗Background and AimsInitial use of drugs such as tobacco and alcohol may lead to subsequent more problematic drug use - the gateway hypothesis. However, observed associations may be due to a shared underlying risk factor, such as trait impulsivity. We used bidirectional Mendelian Randomisation (MR) to test the gateway hypothesis. DesignOur main method was inverse-variance weighted (IVW) MR, with other methods inclu…
Open article record in new tab ↗