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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstBackground and AimsBarretts esophagus (BE) is the principal precursor of esophageal adenocarcinoma (EAC), whose incidence has risen sharply in Western countries since the 1960s. Effective, dysplasia-stratified surveillance strategies are needed to prevent progression. This study evaluated the cost-effectiveness of dysplasia-stratified surveillance intervals and endoscopic eradication therapy (EET) across the BE sp…
Open article record in new tab ↗BackgroundThe risk of esophageal adenocarcinoma (EAC) in Barretts esophagus (BE) varies substantially by segment length and dysplasia grade, yet optimal surveillance strategies remain uncertain. AimsTo evaluate the cost-effectiveness and health impacts of dysplasia-stratified EAC surveillance strategies for the Japanese BE population. MethodsWe developed a state-transition model comparing endoscopy, sponge test, b…
Open article record in new tab ↗Background Esophageal adenocarcinoma (EAC) frequently arises from chronic exposure to acid and bile reflux, with secondary bile acids, such as deoxycholic acid (DCA), contributing to its pathogenesis through mechanisms involving reactive oxygen species (ROS), oxidative DNA damage, and resistance to apoptosis. The human endocannabinoid system (ECS) regulates diverse anti-inflammatory, antioxidant, and analgesic pat…
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