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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
19 articles
Newest firstThe comorbidity of chronic pain and mood disorders poses a clinical challenge involving neurobiological mechanisms within key brain regions like the ventral tegmental area (VTA). We employed a multidisciplinary approach in male mice, combining proteomics, phosphoproteomics, and lipidomics with behavioral and immunohistochemical analyses in a neuropathic pain model. Our findings reveal a temporal evolution of the V…
Open article record in new tab ↗Neuropathic cancer pain (NCP) remains a formidable clinical adversary, severely compromising the quality of life for cancer survivors. Its pathogenesis is highly complex and multifactorial, bifurcated into tumor-induced and chemotherapy-induced neuropathic pain. This review dissects the intricate molecular mechanism of NCP, highlighting how the tumor microenvironment orchestrates neuro-tumor interaction. Bridging…
Open article record in new tab ↗Bridging molecular recognition with scalable materials is a central challenge in polymer science. Here, we present the first comprehensive characterization of LCD-based 3D-printed molecularly imprinted polymers (3DMIPs) with digitally programmable macrogeometries and tunable hierarchical porosity, revealing their optimization potential. As a case study, 3DMIPs targeting the specific enrichment of cannabidiol (CBD)…
Open article record in new tab ↗Cannabis sativa L., a dioecious plant, exhibits sex-specific medicinal active ingredients. However, their causes remain unexplored. In this study, C. sativa flowers exhibited significant intersexual morphological differences, particularly in glandular trichomes. 1676 DEGs and 700 DAMs were identified. Among 149 genes related to sexual differentiation, 77 encode hormone-related products presumably involved in dioec…
Open article record in new tab ↗Bone marrow (BM) mesenchymal stem cells (BM-MSCs) have a crucial role in BM homeostasis and regenerative therapy. While lipids are known to be fundamental components of metabolism, their precise role in modulating the function and behavior of BM-MSCs remains unclear. In this review, we present a comprehensive update on the biology of BM-MSCs in response to fatty acids and cholesterol, which are the major health-re…
Open article record in new tab ↗We are reporting powerful streams of chromatin rupturing the nuclear envelope (NE) and the plasma membrane of migrating cerebral neurons in mouse embryos, which we suggest naming "piercing nuclear hernia" (PNH). About 40% of migrating neurons in cannabinoid type 1 receptor knock-out (CB1R-/-) mouse embryos and in wildtype embryos exposed to CB1R agonists show NE rupture and/or PNH. This indicates that deviations f…
Open article record in new tab ↗Early life exposure to cannabis can result in long-lasting deficits in spatial navigation. We ask if the development of this behavior is subject to early life activity of type I cannabinoid receptor (CB1R) in the vestibular nucleus. In rodents, we found that local exposure to CB1R agonist within the first postnatal week, but not thereafter, led to a decline in the induction efficacy of long-term depression at GABA…
Open article record in new tab ↗Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested whether E/I regulation, rather than the overall E/I ratio, is disrupted in two ASD-related mouse lines: Fmr1 KO and BTBR, models of…
Open article record in new tab ↗Policies regarding cannabis continue to develop worldwide as scientific research into benefits and harms for both therapeutic and recreational use becomes more detailed. Here, we report results from a cross-sectional survey (n = 537) from Finland which aimed to identify factors associated with cannabis use for recreational versus medical purposes. Several demographic and cannabis related factors were used to predi…
Open article record in new tab ↗The endocannabinoid system plays a pivotal role in metabolic regulation, primarily through cannabinoid receptor-1 (CB1) signaling. In this study, we show that rimonabant (Rim), a selective non-restricted CB1 antagonist, induces substantial weight loss across multiple diet groups, although reduced food intake occurred only in the high-fat (HF) diet group. Rim enhanced brown adipose tissue (BAT) thermogenesis across…
Open article record in new tab ↗Cannabinoids interact with cannabinoid receptors, influencing diverse central nervous system (CNS) and peripheral functions, including anxiety, depression, and cognition. CB1 and CB2 receptors modulate signaling cascades via G-protein coupling, with anandamide acting as an endogenous ligand for CB1 receptors. LY-2183240, a putative endocannabinoid transport blocker, elevates brain anandamide levels, showing therap…
Open article record in new tab ↗Endocannabinoids, signaling through the cannabinoid CB1 receptor (CB1R), regulate several forms of neuronal plasticity. CB1Rs in the developing primary visual cortex (V1) play a key role in the maturation of inhibitory circuits. Although CB1Rs were originally thought to reside mainly on presynaptic axon terminals, several studies have highlighted an unexpected role for astrocytic CB1Rs in endocannabinoid mediated…
Open article record in new tab ↗Recent studies have demonstrated the pivotal involvement of endocannabinoids in regulating learning and memory, but the conclusions obtained from different paradigms or contexts are somewhat controversial, and the underlying mechanisms remain largely elusive. Here, we show that JZL195, a dual inhibitor of fatty acid amide hydrolase and monoacylglycerol lipase, can enhance the performance of mice in a contextual fe…
Open article record in new tab ↗Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are diverse among cortical layers, it is unknown whether critical period timing is controlled by a common or unique molecular mechanism among them. We here clarified layer-specific regulation of the critical period timing of ocular dominance plasticity in the primary visual cort…
Cannabidiol (CBD) is on the rise as over-the-counter medication to treat sleep disturbances, anxiety, pain, and epilepsy due to its action on the excitatory/inhibitory balance in the brain. However, it remains unclear if CBD also leads to adverse effects on memory via changes of sleep macro- and microarchitecture. To investigate the effect of CBD on sleep and memory consolidation, we performed two experiments usin…
Open article record in new tab ↗Regeneration after a peripheral nerve injury still remains a challenge, due to the limited regenerative potential of axons after injury. While the endocannabinoid system (ECS) has been widely studied for its neuroprotective and analgesic effects, its role in axonal regeneration and during the conditioning lesion remains unexplored. In this study, we observed that a peripheral nerve injury induces axonal regenerati…
Open article record in new tab ↗SummaryCannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impacts. This trial included 43 adult soccer players (Cannabis group using cannabis at least once a week for the past 6 months, n = 24; non-cannabis control group, n = 19). Tw…
Open article record in new tab ↗The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the precise molecular and physiological basis of reward-seeking behavior remains unknown. We found that the specific deletion of metabo…
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