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Research Article 2024CC BYFree full text

LC-MS/MS-based metabolomics and proteomics reveal the intervention of Kangnian decoction on the postoperative intestinal adhesion of rats.

Liang Jin, Yuan Zhao, Xiaojing Qian, Lingyun Pan, Long Chen, Jingwen Feng +2 more

Background Postoperative Intestinal Adhesions (PIAs) remain a significant complication of abdominal surgery that can cause pain, infertility, and a potentially lethal bowel obstruction. Kangnian (KN) decoction, a Traditional Chinese Medicine prescription, has been shown to be effective in treating PIAs. Nevertheless, its underlying mechanisms remain unclear. Objective This study aims to explore the therapeutic eff…

Frontiers in Pharmacology Europe PMC

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Research Article 2024CC BY-NCFree full text · non-commercial reuse

A UPLC-MS/MS method for simultaneous determination of arachidonic acid, stearic acid, and related endocannabinoids in human plasma.

Xiaojing Qian, Wangzhenzu Liu, Ying Chen, Jiaqi Zhang, Yuanye Jiang, Lingyun Pan +1 more

Endocannabinoids (eCBs) exert considerable influence over energy metabolism, lipid metabolism, and glucose metabolism within the human body. Among the most biologically active cannabinoids identified thus far are 2-arachidonoylglycerol (2-AG), arachidonoyl ethanolamide (AEA), 1-stearoylglycerol (1-SRG), and stearoyl ethanolamide (SEA), which are derived from arachidonic acid (AA) and stearic acid (SA). However, de…

Heliyon Europe PMC

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