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Research Article 2026CC BYFree full text

Preclinical antitumor evaluation of a tetrahydrocannabinol and cannabidiol (1:6) cannabis extract in an MCF-7 xenograft model of estrogen receptor-positive breast cancer.

Nuntana Meesiripan, Somchai Thanasitthichai, Suleeporn Sangrajrang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana +6 more

BACKGROUND AND AIM: Breast cancer remains one of the leading causes of cancer-related mortality worldwide, despite advances in surgery, chemotherapy, endocrine therapy, and targeted treatments. Cannabinoids derived from Cannabis sativa, particularly tetrahydrocannabinol (THC) and cannabidiol (CBD), have demonstrated anticancer properties in several experimental models; however, in vivo evidence in estrogen recepto…

Veterinary World PubMed Central Open Access

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Research Article 2024CC BYFree full text

Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model.

Trung Quang Le, Nuntana Meesiripan, Suleeporn Sanggrajang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana +8 more

Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of the exocrine pancreas. Cannabinoids extracted from the hemp plant Cannabis sativa have been suggested as a potential therapeutic agent in several human tumors. However, the anti-tumor effect of cannabinoids on human PDAC is not entirely clarified. In this study, the anti-proliferative and apoptotic effect of cannabinoid solutio…

Scientific Reports