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Research Article 2019CC BY-NC-SAFree full text · non-commercial reuse

Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of rapamycin-complex 2 and interleukin-10 genes in experimental autoimmune encephalomyelitis.

Soheila Rezapour-Firouzi, Fatemeh kheradmand, Shahram Shahabi, Ali Asghar Tehrani, Ebrahim Mazloomi, Adel Mohammadzadeh

The mammalian target of rapamycin (mTOR) signaling plays a critical role in lipid synthesis and immune responses. The T regulatory cells (Treg) as suppressor of T cells, are a subset of T cells that modulate the immune system, maintain tolerance, and prevent autoimmune diseases.. The interleukin (IL) -10 derived from the Treg and T helper (Th) 2 is an anti-inflammatory cytokine in multiple sclerosis (MS) and exper…

Research in Pharmaceutical Sciences PubMed Central Open Access

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Research Article 2018CC BY-NC-SAFree full text · non-commercial reuse

The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis.

Soheila Rezapour-Firouzi, Shahram Shahabi, Adel Mohammadzadeh, Ali Asgar Tehrani, Fatemeh Kheradmand, Ebrahim Mazloomi

The mammalian target of rapamycin (mTOR) has a fundamental role in the metabolism, growth, and regulation of the immune system. The interferon gamma (IFN-γ)derived from T helper 1 (Th1) cells is a prominent pro-inflammatory cytokine in multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE). Due to the exclusive role of rapamycin (RAPA) in mTOR complex 1 (mTORC1) inhibitio…

Research in Pharmaceutical Sciences