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Research Article 2025CC BY-NC-SAFree full text · non-commercial reuse

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

Emma C. Johnson, Dongbing Lai, Jared V. Balbona, Alex P. Miller, Alexander S. Hatoum, Joseph D. Deak +61 more

Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the…

Psychological Medicine Europe PMC

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Research Article 2023CC BYFree full text

Trends of cannabis use and related harms before and after legalization for recreational purpose in a developing country in Asia.

Rasmon Kalayasiri, Suriyan Boonthae

Background Thailand was the first country in Asia to legalize the use and purchase of cannabis leaves in February 2021 and the whole plant in June 2022 after the 2019 allowance for medical purposes. The study explored trends in cannabis use in Thailand before and after the recreational cannabis allowance was imposed. Methods Cannabis and other variables of substance use, cannabis use disorder, and attitude towards…

BMC Public Health PubMed Central Open Access

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