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19172026

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Author: Nikita Arslanovski

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Research Article 2025CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

The dietary ligands, omega-3 fatty acid endocannabinoids and short-chain fatty acids prevent cytokine-induced reduction of human hippocampal neurogenesis and alter the expression of genes involved in neuroinflammation and neuroplasticity.

Gargi Mandal, Silvia Alboni, Nadia Cattane, Moira Marizzoni, Samantha Saleri, Nikita Arslanovski +5 more

The dietary ligands, omega-3 fatty acid endocannabinoids (eCBs) eicosapentaenoyl ethanolamide (EPEA) and docosahexaenoyl ethanolamide (DHEA), and short-chain fatty acids (SCFAs) acetate, propionate and butyrate, have anti-inflammatory and antidepressant properties. However, the molecular mechanisms underlying their action in the human brain remain elusive. Here, we treated human hippocampal neurons (HPC0A07/03 C)…

Molecular Psychiatry Europe PMC↗

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