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Research Article 2024CC BYFree full text

Comparative Analysis of High-Frequency and Low-Frequency Transcutaneous Electrical Stimulation of the Right Median Nerve in the Regression of Clinical and Neurophysiological Manifestations of Generalized Anxiety Disorder.

Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Irina P Shurygina, Marina M Petrova, Numman Mansur +6 more

Background/Objectives: The anxiolytic effect of transcutaneous electrical nerve stimulation (TENS) is associated with the activation of endogenous inhibitory mechanisms in the central nervous system. Both low-frequency, high-amplitude TENS (LF-TENS) and high-frequency, low-amplitude TENS (HF-TENS) are capable of activating opioid, GABA, serotonin, muscarinic, and cannabinoid receptors. However, there has been no c…

Journal of Clinical Medicine Europe PMC

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Review Article 2022CC BYFree full text

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism.

Elena E. Vaiman, Natalia A. Shnayder, Aiperi K. Khasanova, Anna I. Strelnik, Arseny J. Gayduk, Mustafa Al-Zamil +4 more

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other…

Biomedicines