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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
4 articles
Newest firstLymphatic transport of drugs after oral administration is an important physiological process in highly lipophilic compounds, such as cannabidiol (CBD). The majority of lymphatic transport studies have been historically conducted in anesthetized rats. However, this animal model differs significantly from the humans regarding both anatomical and physiological features. The aim of this study was therefore to develop…
Open article record in new tab ↗Objectives This study aims to assess the anti-inflammatory properties of cannabigerol (CBG) in collagen-induced arthritis (CIA) model in rats, and to determine which inflammatory signaling pathways it affects. Study design Rats were randomized into four groups: placebo (PCB)-p.o. Treated with 1 mL of 0.9% saline once daily, CBG-p.o. Treated with 30 mg of CBG/day, glucocorticoids (GC)-p.o. Treated with methylpredni…
Open article record in new tab ↗Polymorphism remains a major challenge in the development of pharmaceutical solid products as even small changes in the crystal arrangement can influence key properties such as stability and solubility. In this study, we mechanochemically prepared a novel cannabinol piperazine cocrystal, which exists in three polymorphic forms. The formation of these polymorphs was systematically investigated by varying the solven…
Open article record in new tab ↗Background Cannabidiol (CBD) exhibits therapeutic potential due to its analgesic, anxiolytic, anti-inflammatory, and anticonvulsant effects. However, its oral bioavailability is limited by poor water solubility and extensive first-pass metabolism. Formulation strategies such as oil-based emulsions and oil-free particles may overcome these limitations by enhancing solubilization and promoting lymphatic absorption.…
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