Readable research linked to original sources

Articles

Browse normalized, publication-ready research with direct links to its evidence and source.

2 articles

Newest first

Research Article 2015CC BYFree full text

Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats.

Juan M Decara, Francisco Javier Pavón, Juan Suárez, Miguel Romero-Cuevas, Elena Baixeras, Mariam Vázquez +7 more

Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of a novel conjugation of oleic acid with an amphetamine derivative (OLHHA) in an animal model of genetic obesity. Lean and obese Zucker rats received a daily intraperito…

Disease Models & Mechanisms Europe PMC

Open article record in new tab ↗

Research Article 2014CC BYFree full text

Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

Inmaculada Moreno-Santos, Francisco Javier Pavón, Miguel Romero-Cuevas, Antonia Serrano, Carolina Cano, Margarita Suardíaz +4 more

To further understand the pharmacological properties of N-oleoylethanolamine (OEA), a naturally occurring lipid that activates peroxisome proliferator-activated receptor alpha (PPARα), we designed sulfamoyl analogs based on its structure. Among the compounds tested, N-octadecyl-N'-propylsulfamide (CC7) was selected for functional comparison with OEA. The performed studies include the following computational and bi…

PLoS ONE