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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
4 articles
Newest firstCandida auris emerged in Chicago, IL, USA in 2016 and has since become endemic. We used whole genome sequencing (WGS) of 494 isolates, epidemiologic metadata, and patient transfer data to describe the transmission of C. auris among Chicago healthcare facilities between 2016 - 2021. 99% of isolates formed a single clade IV phylogenetic lineage, suggesting a single introduction. Isolates were grouped into genomic cl…
Open article record in new tab ↗BackgroundPathogen whole genome sequencing (WGS) has significant potential for improving healthcare-associated infection (HAI) outcomes. However, methods for integrating WGS with epidemiologic data to quantify risks for pathogen spread remain underdeveloped. MethodsTo identify analytic strategies for conducting WGS-based HAI surveillance in high-burden settings, we modeled patient- and facility-level transmission…
BackgroundCarbapenem-resistant Enterobacterales (CRE) are among the most concerning antibiotic resistance threats due to high rates of multidrug resistance, transmissibility in healthcare settings, and high mortality rates. We evaluated the potential for regional genomic surveillance to track blaKPC-carrying CRE (KPC-CRE) transmission across healthcare facilities in three U.S. states. MethodsClinical isolates were…
Open article record in new tab ↗BackgroundCarbapenem-resistant Enterobacterales (CRE) harboring blaKPC have been endemic in Chicago-area healthcare networks for more than a decade. During 2016-2019, a series of regional point prevalence surveys identified increasing prevalence of blaNDM-containing CRE in multiple long-term acute care hospitals (LTACHs) and ventilator-capable skilled nursing facilities (vSNFs). We performed a genomic epidemiology…
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