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Research Article 2025CC BY-NC-SAFree full text · non-commercial reuse

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

Emma C. Johnson, Dongbing Lai, Jared V. Balbona, Alex P. Miller, Alexander S. Hatoum, Joseph D. Deak +61 more

Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the…

Psychological Medicine Europe PMC

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Research Article 2025CC BYFree full text

Cannabinoid Receptor Type 1 Availability in Individuals with a History of Childhood Trauma: A Positron Emission Tomography Study

ANAHITA BASSIR NIA, Ardavan Mohammad Aghaei, Brian Pittman, Nachshon Korem, Deepak D’Souza, Marc Potenza +3 more

Abstract Early life adversity has a lasting impact on the endocannabinoid (eCB) system based on animal models. However, the impact of early life adversity such as childhood trauma (CT) on the eCB system has not been thoroughly studied. We assessed the availability of cannabinoid receptor type 1 (CB1R) in individuals with CT compared to healthy controls without CT (HCs). Cannabinoid receptor type 1 (CB1R) availabil…

Research Square PubMed Central Open Access

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