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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
5 articles
Newest firstMapping chromatin quantitative trait loci (cQTLs) is crucial for elucidating the regulatory mechanisms governing gene expression and complex traits. However, current cQTL mapping methods suffer from limited detection power, particularly at existing sample sizes, and are constrained by peak-calling accuracy. To address these limitations, we present CACTI, a novel method that improves cQTL mapping by leveraging corr…
Open article record in new tab ↗Background and objective: Cannabinoids are commonly used as adjuvant cancer drugs to overcome numerous adverse side effects for patients. The aim of this study was to identify the target genes that show a synergistic anti-tumor role in combination with the cannabinoid WIN55212-2 in vitro and in vivo. Methods: A human kinome RNAi library was used to screen the targeted gene that silencing plus WIN55212-2 treatment…
Open article record in new tab ↗Historical ethnobotanies of indigenous peoples of the North American prairies reveal treatment of many painful conditions by Echinacea spp. Recent evidence suggests a pharmacological basis for such use as the bioactivity of E. angustifolia and E. purpurea is mediated, in part, through activation of the endocannabinoid system (ECS). Whereas the cannabimimetic effects of individual echinacea products and alkylamides…
Open article record in new tab ↗The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity while avoiding these central nervous system side effects. In the current study, a novel compound (TXX-522) was rationall…
Open article record in new tab ↗[This corrects the article on p. 707 in vol. 8, PMID: 29051736.].
Open article record in new tab ↗