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Research Article 2012CC BYFree full text

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.

Laurie Hamtiaux, Julien Masquelier, Giulio G Muccioli, Caroline Bouzin, Olivier Feron, Bernard Gallez +1 more

Background The incidence of melanoma is considerably increasing worldwide. Frequent failing of classical treatments led to development of novel therapeutic strategies aiming at managing advanced forms of this skin cancer. Additionally, the implication of the endocannabinoid system in malignancy is actively investigated. Methods We investigated the cytotoxicity of endocannabinoids and their hydrolysis inhibitors on…

BMC Cancer Europe PMC

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Research Article 2011CC BYFree full text

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.

Laurie Hamtiaux, Laurie Hansoulle, Nicolas Dauguet, Giulio G. Muccioli, Bernard Gallez, Didier M. Lambert

The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity of three N-acylethanolamines--N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) an…

PLoS ONE Europe PMC

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