Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
6 articles
Newest firstPeople with narcolepsy experience delays in diagnosis and inconsistent post-diagnosis care, but the pattern and scale of their healthcare use is poorly described. In this population-based cohort study, we used primary care and linked hospital activity data to compare healthcare use in people with narcolepsy (n=2,772) and a matched comparison group in England (n=13,860). Narcolepsy was defined by a first coded reco…
Open article record in new tab ↗BackgroundMost analyses of excess mortality during the COVID-19 pandemic have employed aggregate data. Individual-level data from the largest integrated healthcare system in the US may enhance understanding of excess mortality. MethodsWe performed an observational cohort study following patients receiving care from the Department of Veterans Affairs (VA) between 1 March 2018 and 28 February 2022. We estimated exce…
ObjectivesTo compare the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines against infection and COVID-19 disease in health and social care workers. DesignCohort study, emulating a comparative effectiveness trial. SettingLinked primary care, hospital, and COVID-19 surveillance records available within the OpenSAFELY-TPP research platform. Participants317,34…
Open article record in new tab ↗BackgroundThere is concern about medium to long-term adverse outcomes following acute COVID-19, but little relevant evidence exists. We aimed to investigate whether risks of hospital admission and death, overall and by specific cause, are raised following discharge from a COVID-19 hospitalisation. Methods and FindingsWorking on behalf of NHS-England, we used linked primary care and hospital data in OpenSAFELY to c…
Open article record in new tab ↗BackgroundThe COVID-19 pandemic has disrupted healthcare activity globally. The NHS in England stopped most non-urgent work by March 2020, but later recommended that services should be restored to near-normal levels before winter where possible. The authors are developing the OpenSAFELY NHS Service Restoration Observatory, using data to describe changes in service activity during COVID-19, and reviewing signals fo…
Open article record in new tab ↗BackgroundClose contact with children may provide cross-reactive immunity to SARs-CoV-2 due to more frequent prior coryzal infections from seasonal coronaviruses. Alternatively, close contact with children may increase risk of SARs-CoV-2 infection. We investigated whether risk of infection with SARs-CoV-2 and severe outcomes differed between adults living with and without children. MethodsWorking on behalf of NHS…
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