Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
6 articles
Newest firstBackground China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Methods Based on summary statistics of existing genome-wide association studies in East Asian ancestry (EAS) and European ancestry (EUR) populations, we tested the associations of polygenic scores (PGSs) for schizophrenia (SCZ) and major depression (MD) with 25…
Open article record in new tab ↗BackgroundCare delivery in conventional health systems is structured around clinical anatomical specialties, often geared towards managing single conditions rather than people. As a result, people with Multiple Long-Term Conditions (MLTC) often need to see many different specialists to manage their health, resulting in fragmented care that is inefficient and costly. Certain Long-term Conditions (LTCs) frequently c…
Open article record in new tab ↗BackgroundMedication errors are the leading cause of preventable harm in healthcare. Despite proliferation of medication-related clinical decision support systems (CDSS), current systems have limitations. We therefore developed an indication-based prescribing tool. This performs dose calculations using an underlying formulary and provides patient-specific dosing recommendations. Objectives were to compare the inci…
Open article record in new tab ↗Natural language processing (NLP) is increasingly being applied to obtain unsupervised representations of electronic healthcare record (EHR) data, but their performance for the prediction of clinical endpoints remains unclear. Here we use primary care EHRs from 6,286,233 people with Multiple Long-Term Conditions in England to generate vector representations of sequences of disease development using two input strat…
Open article record in new tab ↗Identifying clusters of co-occurring diseases can aid understanding of shared aetiology, management of co-morbidities, and the discovery of new disease associations. Here, we use data from a population of over ten million people with multimorbidity registered to primary care in England to identify disease clusters through a two-stage process. First, we extract data-driven representations of 212 diseases from patie…
Open article record in new tab ↗BackgroundClinical practice guidelines (CPGs) aim to standardize clinical care. Increasingly, hospitals rely on locally produced guidelines alongside national guidance. This study examines variation between national and local CPGs, using the example of acute paediatric asthma guidance from the United Kingdom and the Netherlands. MethodsFifteen British and Dutch local CPGs were collected with the matching national…