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Research Article 2025CC BYFree full text

Three-day delta-9-tetrahydrocannabinol (THC) exposure eliminates long-term depression in ventral tegmental area of young, but not adult mice.

Michael Von Gunten, Seth Hoffman, Addison Smartt, Jeffrey G Edwards

Ventral tegmental area (VTA) dopamine signaling plays a key role in reward learning and drug dependence. VTA dopamine cell activity is regulated in part by local GABA interneurons, which participate in regulating reward prediction. Previously, our lab identified a cannabinoid type 1 receptor (CB1)-dependent form of excitatory long-term depression (LTD) in VTA GABA cells. LTD was eliminated in both young and adult…

Journal of Cannabis Research Europe PMC

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Editorial 2022CC BYFree full text

Editorial: The Emerging Role of Endocannabinoids in Synaptic Plasticity, Reward, and Addiction.

Jeffrey G Edwards, Luigia Cristino, Dan P Covey

Frontiers in Synaptic Neuroscience Europe PMC

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Research Article 2019CC BYFree full text

Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes.

Lindsey N Friend, Ryan C Williamson, Collin B Merrill, Scott T Newton, Michael T Christensen, Jake Petersen +4 more

The hippocampus is thought to encode information by altering synaptic strength via synaptic plasticity. Some forms of synaptic plasticity are induced by lipid-based endocannabinoid signaling molecules that act on cannabinoid receptors (CB1). Endocannabinoids modulate synaptic plasticity of hippocampal pyramidal cells and stratum radiatum interneurons; however, the role of endocannabinoids in mediating synaptic pla…

Molecules Europe PMC

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