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Author: Jean Dinh

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Research Article 2025CC BY-NCCC BY-NC allows this article to remain publicly readable here. Reuse is limited to non-commercial use and the recorded source terms.Free full text · non-commercial reuse

Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta-9-Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes.

Lixuan Qian, Tao Zhang, Jean Dinh, Mary F Paine, Zhu Zhou

The two most extensively studied cannabinoids, cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), are used for myriad conditions. THC is predominantly eliminated via the cytochromes P450 (CYPs), whereas CBD is eliminated through both CYPs and UDP-glucuronosyltransferases (UGTs). The fractional contributions of these enzymes to cannabinoid metabolism have shown conflicting results among studies. Physiologica…

Clinical and Translational Science Europe PMC↗

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