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Research Article 2023CC BYFree full text

Inhibition of synaptic transmission by anandamide precursor 20:4-NAPE is mediated by TRPV1 receptors under inflammatory conditions.

Diana Spicarova, Vladimir Nerandzic, David Muzik, Monica Pontearso, Anirban Bhattacharyya, Istvan Nagy +1 more

Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 (CB1) are essential in the modulation of nociceptive signaling in the spinal cord dorsal horn that underlies different pathological pain states. TRPV1 and CB1 receptors share the endogenous agonist anandamide (AEA), produced from N-arachidonoylphosphatidylethanolamine (20:4-NAPE). We investigate…

Frontiers in Molecular Neuroscience Europe PMC

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Research Article 2016CC BYFree full text

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Jie Chen, Angelika Varga, Srikumaran Selvarajah, Agnes Jenes, Beatrix Dienes, Joao Sousa-Valente +7 more

The cannabinoid type 1 (CB1) receptor and the capsaicin receptor (TRPV1) exhibit co-expression and complex, but largely unknown, functional interactions in a sub-population of primary sensory neurons (PSN). We report that PSN co-expressing CB1 receptor and TRPV1 form two distinct sub-populations based on their pharmacological properties, which could be due to the distribution pattern of the two receptors. Pharmaco…

Scientific Reports Europe PMC

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