Striatal endocannabinoids drive one-shot learning.

Charlotte Piette, Arnaud Hubert, Sylvie Perez, Jérémy Peixoto, Nicolas Gervasi, Hugues Berry +2 more

One-shot learning-the ability to form memories after a single, brief salient event-is essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies on distinct plasticity mechanisms remains unknown. Here we show that a nonclassical plasticity mechanism requiring only a few stimulations-endocannabinoid-mediated long-term potentiation (eCB-LTP)-und…

Striatal endocannabinoid-long-term potentiation mediates one-shot learning

Charlotte Piette, Arnaud Hubert, Sylvie Perez, Hugues Berry, Jonathan Touboul, Laurent Venance

One-shot learning, the ability to form memories after a single, brief salient event, is essential to adapt one’s behaviour in a dynamic world. However, how one-shot learning unfolds in the brain remains unknown. Challenges to elucidate its neural underpinnings stem experimentally from the scarcity of behavioral assays recapitulating one-shot learning in the laboratory, and conceptually from the limited number of n…

Endocannabinoids mediate spike-timing dependent potentiation and depression: a model-based experimental approach

Yihui Cui, Vincent Paille, Bruno Delord, Stéphane Genet, Elodie Fino, Laurent Venance +1 more