Striatal endocannabinoids drive one-shot learning.

Charlotte Piette, Arnaud Hubert, Sylvie Perez, Jérémy Peixoto, Nicolas Gervasi, Hugues Berry +2 more

One-shot learning-the ability to form memories after a single, brief salient event-is essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies on distinct plasticity mechanisms remains unknown. Here we show that a nonclassical plasticity mechanism requiring only a few stimulations-endocannabinoid-mediated long-term potentiation (eCB-LTP)-und…