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Other 2021CC BYFree full text

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19.

Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, MF Nagoor Meeran, Hayate Javed +3 more

Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with adv…

Frontiers in Pharmacology PubMed Central Open Access

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Research Article 2016CC BYFree full text

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease.

Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojha

The cannabinoid type two receptors (CB2), an important component of the endocannabinoid system, have recently emerged as neuromodulators and therapeutic targets for neurodegenerative diseases including Parkinson's disease (PD). The downregulation of CB2 receptors has been reported in the brains of PD patients. Therefore, both the activation and the upregulation of the CB2 receptors are believed to protect against…

Frontiers in Neuroscience Europe PMC

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