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Research Article 2025CC BYFree full text

Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats.

Hakan Kayir, Larissa Kouroukis, Iman Aziz, Jibran Younis Khokhar, Francisco Navarrete, María S García Gutiérrez

Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1 receptor agonist/antagonist and a partial CB2 agonist. This study evaluated the effects of THCV in a THC discrimination model in rats. Male Sprague-Dawley rats (n = 16, 300-340 g, PND60) were trained under a fixed ratio 20 (FR20) schedule to discriminate THC (3 mg/…

Biomolecules Europe PMC

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Brief Report 2021CC BYFree full text

Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism During Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats.

Danna Ellner, Bryana Hallam, Jude A Frie, Hayley H A Thorpe, Muhammad Shoaib, Hakan Kayir +2 more

The endocannabinoid system is responsible for regulating a spectrum of physiological activities and plays a critical role in the developing brain. During adolescence, the endocannabinoid system is particularly sensitive to external insults that may change the brain's developmental trajectory. Cannabinoid receptor type 2 (CB2R) was initially thought to predominantly function in the peripheral nervous system, but mo…

Frontiers in Synaptic Neuroscience Europe PMC

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