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Research Article 2023CC BYFree full text

Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats.

Laura Rullo, Loredana Maria Losapio, Camilla Morosini, Francesca Mottarlini, Sara Schiavi, Valeria Buzzelli +8 more

Social and emotional experiences differently shape individual's neurodevelopment inducing substantial changes in neurobiological substrates and behavior, particularly when they occur early in life. In this scenario, the present study was aimed at (i) investigating the impact of early social environments on emotional reactivity of adolescent male and female rats and (ii) uncovering the underlying molecular features…

Frontiers in Cellular Neuroscience Europe PMC

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Research Article 2022CC BYFree full text

Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network.

Francesca Mottarlini, Marco Fumagalli, Fernando Castillo-Díaz, Stefano Piazza, Giorgia Targa, Enrico Sangiovanni +5 more

Cannabidiol (CBD) is a phytocannabinoid contained in the Cannabis sativa plant, devoid of psychotomimetic effects but with a broad-spectrum pharmacological activity. Because of its pharmacological profile and its ability to counteract the psychoactive Δ9-tetrahydrocannabinol (Δ9THC), CBD may be a potential treatment for several psychiatric and neurodegenerative disorders. In this study, we performed a dose-respons…

Biomedicines Europe PMC

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