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Research Article 2023CC BYFree full text

Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond.

Filip Koniuszewski, Florian D Vogel, Irena Dajić, Thomas Seidel, Markus Kunze, Matthäus Willeit +1 more

Introduction Medications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics. All benzodiazepines and several nonbenzodiazepine Z-drugs share high affinity binding sites on certain subtypes of GABAA receptors, from which they can be displaced by the clinically used antagoni…

Frontiers in Psychiatry Europe PMC

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Research Article 2022CC BYFree full text

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels.

Filip Koniuszewski, Florian D Vogel, Konstantina Bampali, Jure Fabjan, Thomas Seidel, Petra Scholze +3 more

Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABAARs) and glycine receptors (GlyRs). They are recognized therapeutic targets of some of the most prescribed drugs like general anesthetics, anxiolytics, smoking cessation aids, ant…

Frontiers in Molecular Biosciences

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