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Author: Edward T Wargent

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Research Article 2020CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain.

Edward T Wargent, Malgorzata Kepczynska, Mohamed Sghaier Zaibi, David C Hislop, Jonathan RS Arch, Claire J Stocker +1 more

Background The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist or an antagonist depending on the assay). The cannabinoid receptor type 1 (CB1R) inverse agonist rimonabant is also a GPR55 agonist under some conditions. Previous studies have shown varied effects of deletion of GPR55 on energy balance and…

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