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Research Article 2022CC BYFree full text

Cannabidiol but not cannabidiolic acid reduces behavioural sensitisation to methamphetamine in rats, at pharmacologically effective doses.

Laísa S. Umpierrez, Priscila A. Costa, Eden A. Michelutti, Sarah J. Baracz, Melanie Sauer, Anita J. Turner +4 more

Rationale Cannabidiol (CBD) and cannabidiolic acid (CBDA) are non-psychoactive components of the cannabis plant. CBD has been well characterised to have anxiolytic and anticonvulsant activity, whereas the behavioural effects of CBDA are less clear. Preclinical and clinical data suggests that CBD has antipsychotic properties and reduces methamphetamine self-administration in rats. An animal model that is commonly u…

Psychopharmacology Europe PMC

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Research Article 2022CC BYFree full text

Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks.

Mehdi Mirzaei, Morteza Abyadeh, Anita J. Turner, Roshana Vander Wall, Joel M. Chick, Joao A. Paulo +11 more

Fingolimod (FTY720) is an oral drug approved by the Food and Drug Administration (FDA) for management of multiple sclerosis (MS) symptoms, which has also shown beneficial effects against Alzheimer's (AD) and Parkinson's (PD) diseases pathologies. Although an extensive effort has been made to identify mechanisms underpinning its therapeutic effects, much remains unknown. Here, we investigated Fingolimod induced pro…

Proteomics