Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
9 articles
Newest firstWe present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most common outpatient medical codes from each of three data types/modalities - ICD-9 (Dx), Current Procedural Terminology (CPT), and prescription drugs (R…
Open article record in new tab ↗ObjectiveBy personalizing healthcare to an individuals specific requirements, precision health promises to maximize benefit and minimize harm, thereby maximizing value. We describe here, how in Phase 2 of the Million Veteran Program-Computational Health Analytics for Medical Precision to Improve Outcomes Now (MVP-CHAMPION), artificial intelligence (AI) and high performance computing (HPC) have been applied to Vete…
Open article record in new tab ↗BackgroundMost analyses of excess mortality during the COVID-19 pandemic have employed aggregate data. Individual-level data from the largest integrated healthcare system in the US may enhance understanding of excess mortality. MethodsWe performed an observational cohort study following patients receiving care from the Department of Veterans Affairs (VA) between 1 March 2018 and 28 February 2022. We estimated exce…
Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included seve…
Open article record in new tab ↗BackgroundSome payors and clinicians require alcohol abstinence for direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection. ObjectiveTo evaluate whether alcohol use at DAA treatment initiation was associated with decreased odds of sustained virologic response (SVR). DesignObservational cohort study using electronic health records. SettingUS Department of Veterans Affairs (VA), the larg…
Open article record in new tab ↗ImportanceThe COVID-19 pandemic had a substantial impact on the overall rate of death in the United States during the first year. It is unclear whether access to comprehensive medical care, such as through the VA healthcare system, altered death rates compared to the US population. ObjectiveQuantify the increase in death rates during the first year of the COVID-19 pandemic in the general US population and among in…
Open article record in new tab ↗ObjectivesTo determine whether early oral or parenteral corticosteroids compared to no corticosteroids are associated with decreased mortality in patients hospitalized with coronavirus disease 2019 (COVID-19) who are not on intensive respiratory support (IRS) within 48 hours of admission. DesignObservational cohort study SettingNationwide cohort of patients receiving care in the Department of Veterans Affairs, a l…
Open article record in new tab ↗BackgroundThe Veterans Health Administration COVID-19 (VACO) Index incorporates age, sex, and pre-existing comorbidity diagnoses readily available in the electronic health record (EHR) to predict 30-day all-cause mortality in both inpatients and outpatients infected with SARS-CoV-2. We examined the performance of the Index using data from Yale New Haven Hospital (YNHH) and national Medicare data overall, over time…
Open article record in new tab ↗BackgroundThere is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of morbidity and mortality from symptomatic SARS-Cov-2 infection or coronavirus disease 2019 (Covid-19). Most studies investigating racial and ethnic disparities to date have focused on hospitalized patients or have not characterized who received testing or those who tested pos…
Open article record in new tab ↗