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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstIntroduction Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta-analysis, related to weight-change over time in people with first episode-psychosis…
Open article record in new tab ↗ObjectivesTo assess the degree to which we can replicate a study between a regional and a national database of electronic health record data in the United Kingdom. DesignA replication of a retrospective cohort study. SettingObservational EHR data from primary and secondary care sources in the UK. The original study used data from a large, urbanised region (Greater Manchester Care Record, Greater Manchester, UK). T…
ObjectiveThe ability to reproduce the work of others is an essential part of the scientific disciplines. Replicating observational studies using electronic health record (EHR) data can be challenging due to complexities in data access, variations in EHR systems across institutions, and the potential for unaccounted confounding variables. Our aim is to identify the barriers to methods reproducibility for replicatio…