To our knowledge, this is the first study to examine substance use and disordered eating risks associated with OCD conditions among young adult college students in the U.S. as well as how these associations may vary among cisgender male, cisgender female, and TGNC students. Our findings show that overall, college students with OCD conditions showed higher prevalence of medium/high alcohol, tobacco, and cannabis involvement and disordered eating risk compared to their counterparts without OCD conditions. Even when accounting for stress, depression, and anxiety, having an OCD condition was associated with greater likelihood of medium/high alcohol, tobacco, cannabis, and disordered eating risk; however, the associations varied by sex/gender.

Previous studies have reported that due to the similarities in their phenomenology, and the increased likelihood of individuals with OCD to turn to substances to self-medicate and alleviate distress caused by obsessive thoughts and compulsive behaviors, there is a high level of comorbidity between OCD and substance use risk and disorder [10, 11, 26]. In line with these studies, we found that OCD conditions were associated with elevated odds of medium/high alcohol, tobacco, and cannabis use risk. Although most of the previous studies were conducted among a general adult population and in international samples [26], our study extends current knowledge by demonstrating the association of OCD conditions with medium/high risk alcohol, tobacco, and cannabis use in a U.S. sample among a population subgroup (young adult college students, 18–24 years) that comprises a significant fraction of the U.S. population (38%) and represents a large proportion of new OCD diagnoses [27–29].

OCD and substance misuse share similar neurological and genetic influences [26]. However, there is heterogeneity in their presentation due to the interaction between genetic and biological risk factors and a range of environmental influences [30, 31]. The elevated odds of alcohol, tobacco, and cannabis use among students with OCD may reflect these shared influences, as well as the unique risks posed by the college environment. College campuses are unique environments that foster high-risk substance use (e.g., polysubstance use) through factors like Greek life affiliations [32], academic stress [33], and social norms that encourage substance use [34]. Given that OCD is a multifactorial condition influenced by environmental contexts, students with OCD may be particularly vulnerable to substance use disorders in such settings. Our findings underscore the importance of incorporating regular substance use screenings into the clinical care of college students with OCD. Furthermore, tailoring support systems to address both the anxiety and compulsions characteristic of OCD and the environmental triggers unique to college life is essential for promoting the well-being of these students.

In line with studies indicating that sex/gender significantly influences the expression and impact of OCD [1, 5, 35, 36], this study demonstrates that the risks and comorbidities associated with OCD among college students vary by sex/gender. Even after accounting for other stress and mental health symptoms, cisgender females with OCD had a higher risk of comorbidity related to medium/high alcohol, tobacco, and cannabis use as well as disordered eating. TGNC students with OCD conditions were at risk for both medium/high tobacco use and disordered eating while cisgender males with OCD conditions showed an elevated risk only for disordered eating. Our results fill a crucial gap and advance the literature by providing sex/gender-stratified evidence from a U.S.-based population subgroup (traditional age college students) that is not currently represented in the literature.

Earlier studies have reported mixed findings regarding gender, OCD symptomatology, and comorbid conditions [5, 35, 37]. For example, one study found no difference in the prevalence of lifetime comorbidities between males and females [37], another reported an elevated risk of substance use disorder risk among males [1], and yet another found elevated risk of social phobia and eating disorders among females [5]. While no studies have specifically addressed OCD comorbidities among TGNC individuals, the mixed findings for cisgender males and females may stem from differences in study populations (children vs. adults vs. college students; community vs. clinical samples) or the geographical context (i.e. different countries) [37]. Another possible explanation for this variability could be sex/gender differences in symptom onset and presentation [37]. For example, males with OCD conditions are more likely to exhibit social anxiety disorder and tic disorders, while females are more prone to eating and impulse control disorders [37]. Additionally, research has shown that cisgender women and TGNC individuals often experience heightened psychological distress related to social expectations discrimination, and internalized stigma which may exacerbate obsessive-compulsive behaviors and increase their risk of medium/high substance use and disordered eating [38]. The observed sex/gender variability in risks and comorbidities associated with OCD among college students may also stem from cultural influences and socioenvironmental factors interacting with biological predispositions that shape risk behaviors [35]. These findings emphasize that while all college students with OCD conditions are an at-risk group, cisgender female students face the highest risks and should be prioritized for tailored interventions and programs to support healthy symptom management and effective treatment planning. Moreover, the results highlight the significant sex/gender differences in the complex interplay between psychosocial stressors, OCD symptomatology, and maladaptive coping behaviors, underscoring the need for nuanced approaches to address these challenges.

Among non-college populations, there is evidence showing a high comorbidity between eating disorders (EDs) and OCD, attributed to their shared genetic and psychological features [16]. It is therefore not surprising that, among young adult college students with OCD conditions, EDs emerged as the only consistent comorbid risk. However, unlike previous studies that identified cisgender females with OCD as the primary groups at elevated risk for EDs [5, 39], our findings revealed that among college students, all sexes/genders are at greater risk, with predicted risk probabilities highest among TGNC students. This highlights the unique comorbid risks associated with OCD conditions among college students.

First, it is important to note that the disordered eating variable examined in this study encompassed multiple disorders including anorexia nervosa, bulimia nervosa, and binge eating. College students are particularly vulnerable to body dissatisfaction, weight concerns, and appearance-related stress, which are amplified by the college environment and life stage. Disordered eating behaviors, such as restrictive eating, binge eating, and purging, are prevalent in this population and are further exacerbated by stress related to academic performance, relationship challenges, and the transition to college life [40, 41]. Both OCD and EDs often involve ritualistic behaviors as well as intrusive thoughts including those related to body image, weight, and food. The heightened risk of EDs among students with OCD conditions is especially concerning because college students are at a developmental stage marked by susceptibility to mental disorders [42], reluctance to seek professional help [43], and the formation of long-term behavioral patterns that influence their quality of life, chronic disease risks, and overall health. The pervasive risk of EDs among cisgender males, cisgender females, and TGNC students with OCD conditions underscores the need for comprehensive mental health screening and tailored support systems within college settings.

In summary, our findings show that college students with OCD conditions—a complex, multifaceted disorder with comorbidity risks varying by sex/gender—are an at-risk group for engaging in various risk behaviors. However, these results should be interpreted within the context of our study limitations. First, while this study employed one of the best national datasets available on college students’ health which includes data on diverse racial and gender identities, it is not nationally representative of college students in the U.S. Additionally, the cross-sectional nature of the data preclude the ability to establish causality and the limited confounder adjustment (e.g., no data on other mental health issues such as PTSD, sleep disorders) could influence study outcomes. It is also important to note that OCD and ED measures examined in the study were based on self-reported, single-item measures regarding clinically diagnosed conditions. Although these measures are useful for screening purposes, they do not allow us to disentangle specific eating disorder type (e.g., anorexia nervosa, binge eating) or obsessive compulsive and related disorders (e.g., perseverative thoughts, repetitive behaviors, body dysmorphia, hoarding, trichotillomania) that may have been the primary drivers of reported associations. Furthermore, although the sample included TGNC students, the relatively small size of this subgroup may have limited the study’s power to detect additional associations. Despite these limitations, this study’s contributions to the extant literature fill an important knowledge gap on the risks associated with OCD conditions among young adults in the U.S.

This study represents a pioneering investigation of the complex interplay between OCD conditions, substance use, and disordered eating risks among U.S. young adult college students. Our findings reveal that students with OCD conditions have a higher prevalence of medium/high risk alcohol, tobacco, and cannabis use and disordered eating compared to their counterparts without such conditions, even after adjusting for stress, depression, and anxiety. Although cisgender male, cisgender female, and TGNC students with OCD conditions were at greater risk for eating disorders, TGNC students exhibited the highest predicted risk probability while cisgender females had the greatest comorbidity risks. The study underscores the unique challenges posed by the college environment and life-stage—where substance use and disordered eating behaviors are amplified—that may predispose young adults with OCD to developing substance use and eating disorders. The heightened risk for eating disorders emphasizes the significance of comprehensive mental health screening and support on college campuses. Our findings contribute valuable insights into the underexplored intersection of OCD, substance use, and disordered eating risks among college students, highlighting the imperative for future research to unravel the intricate sex/gender differences in the biopsychosocial mechanisms underlying these associations.