In this longitudinal cross-sectional study, we measured Google searches that mentioned “CBD” or “cannabidiol” emerging from the United States (including by state) from January 1, 2004, through April 23, 2019. We report these measurements as query fractions (QFs), which are the number of searches per every 10 million searches originating nationally or from a respective state. We forecasted searches through 2019 using an autoregressive integrated moving average model, with components estimated using the algorithm developed by Hyndman and Khandakar² and data from all months since 2014. This model is robust to time series biases such as recurring periodicities. We also contrasted search volumes during April 2019 for CBD against those for several health topics, products, or alternative medicines, including acupuncture, apple cider vinegar, diet (excluding “Coke” or “Pepsi”), electronic cigarettes (“e cig/s,” “e cigarette/s,” “electronic cigarette/s,” “vape,” “vaping,” or “vapor,” excluding “marijuana” or “cannabis”), exercise, marijuana (“marijuana” or “cannabis”), meditation, vaccines (“vaccine/s,” “vaccinate/d,” or “vaccination”), veganism, and yoga. Raw search counts were inferred using estimates from the media measurement and analytics company Comscore. Analyses were performed using R statistical software version 3.5.2 (R Project for Statistical Computing) and followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cross-sectional studies. Ethical review by the institutional review board was not required per 45 CFR part 46 and the standard operating policies and procedures at the University of California, San Diego, which do not require review of studies that do not involve intervention or interaction with individuals and use information that is not individually identifiable.