Abstract Japanese study collects data samples from 349 patients across 45 sites since 2014. Examining PSP/CBS patients’ initial symptoms, revealing…
Abstract A 72-year-old man presented with a 6-month history of decreased voluntary speech. Sparse speech and decreased word fluency were…
Abstract Purpose: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Abstract Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in…
Abstract Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances (ref. 1–ref. 3). A…
Abstract The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer’s disease (AD), we previously…
Abstract Purpose: Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of…
Abstract Background: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why…