Novel tau filament fold in corticobasal degeneration

Abstract Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances (ref. 1–ref. 3). A higher frequency of the H1 haplotype of MAPT, the tau gene, is present in cases of CBD than in controls (ref. 4,ref. 5) and genome-wide association studies have identified additional risk factors (ref. 6). By histology, astrocytic plaques are diagnostic of CBD (ref. 7,ref. 8), as are detergent-insoluble tau fragments of 37 kDa by SDS-PAGE (ref. 9). Like progressive supranuclear