FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
Abstract FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long…
Chunxi Wang
Exploring the multifaceted roles of glutamate oxaloacetate transaminase 1 as a biomarker and therapeutic target in colorectal cancer and pan-cancer analyses
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03461-8. Article type: Research Article Keywords: Colorectal cancer, Glutamate…
A pan-cancer analysis of the oncogenic function of HMGB1 in human tumors
Abstract Background: Although high mobility group box protein 1 (HMGB1) has been researched in relation to cancer in many investigations,…
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Abstract Background: Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified small…
Establishment of a human organoid-based evaluation system for assessing interspecies infection risk of animal-borne coronaviruses
Abstract The COVID-19 pandemic presents a major threat to global public health. Several lines of evidence have shown that the…
DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein
Abstract Neutrophil extracellular traps (NETs) are produced through ejection of genomic DNA by neutrophils into extracellular space and serve as…
Distinct Roles of Adenosine Deaminase Isoenzymes ADA1 and ADA2: A Pan-Cancer Analysis
Abstract Objective: Adenosine deaminase (ADA) plays an important role in immune response, which includes two isoenzymes: ADA1 and ADA2. This…
Effect of Megestrol Acetate Combined With Oral Nutrition Supplement in Malnourished Lung Cancer Patients: A Single-Center Prospective Cohort Study
Abstract Background: The optimal treatment of cancer-related malnutrition remains unknown. A single-center prospective cohort study was performed to compare the…
NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway
Abstract As an AAA-ATPase, Vps4 is important for function of multivesicular bodies (MVB) sorting pathway, which involves in cellular phenomena…
Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis
Abstract Nosiheptide is a parent compound of thiopeptide family that exhibit potent activities against various bacterial pathogens. Its C-terminal amide…